Danny Barlow vs. Djorden Santos prediction, odds, pick for UFC Vancouver

UFC Vancouver continues from Rogers Arena as we’re set for an additional betting prediction and pick with this next bout happening within the Middleweight (185) Division. Contender Series alum face off as Danny Barlow of Tennessee takes on Brazil’s Djorden Santos. Take a look at our UFC odds series for the Barlow-Santos prediction and pick.

Danny Barlow (9-1) has gone 2-1 since joining the UFC roster in 2024. He managed a viral knockout in his debut against Josh Quinlan but most recently fell to Sam Patterson via knockout in the primary round. He’ll be trying to prove himself once more because the heavy favorite here. Barlow stands 6-foot-2 with a 79-inch reach.

Djorden Santos (10-2) makes his second UFC appearance following an unsuccessful debut against Ozzy Diaz falling via unanimous decision. The loss broke a five-fight winning streak prior to his UFC arrival, so he’ll proceed chasing that elusive first win on this one. Santos stands six feet tall with a 75.5-inch reach.

Listed here are the UFC Vancouver Odds, courtesy of DraftKings. 

UFC Vancouver odds: Danny Barlow-Djorden Santos odds

Danny Barlow: -325

Djorden Santos: +260

Over 2.5 rounds: +120

Under 2.5 rounds: -154

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Why Danny Barlow will win

• Last Fight: (L) Sam Patterson – TKO (right hook, R1)
• Last 5: 4-1
• Finishes: 5 KO/TKO, 1 SUB

After two blazing fights to open his UFC run, Barlow tasted the primary defeat of his pro profession against Sam Patterson in March 2025. The primary-round knockout was a humbling moment for the undefeated fighter, but Barlow is the sort to learn from his mistakes and evolve with each passing fight. Expect to see the most effective version of him come Saturday night, each within the cage and on the scales because the more physically gifted fighter.

Danny Barlow may be very long for this weight class and uses his reach to gauge opponents’ distance before loading up for his power shots. It’s value noting that his Barlow’s last win got here when he was heavy on the scales prior to the bout, so the hope is that he’s capable of lock in his cut and training camp ahead of this fight. His cardio should not be an excessive amount of of a problem, but we will not imagine he wants to tug this fight out in any respect.

Barlow must have all of the noticeable benefits on the feet so long he’s capable of keep the fight standing. Santos’ is the significantly better grappler, but Barlow sports an ideal 100% takedown defense rate coming into this fight. Santos has been known to shoot for the one legs along the fence, but we must always see Barlow confidently stuffing the attempts and dealing from range.

Why Djorden Santos will win

• Last Fight: (L) Ozzy Diaz – U DEC
• Last 5: 4-1
• Finishes: 3 KO/TKO, 4 SUB

Djorden Santos lost a convincing decision to Ozzy Diaz during his UFC debut clearly unable to shake the offense getting back from his opponent. Still, Santos stood his ground and made for an exciting fight, so he’ll keep earning spots like this if he’s capable of placed on a show for the fans. If he’s capable of catch Danny Barlow off guard for even a second, it may very well be the opening Santos must flip the script on this bout.

Santos has a solid history of submission grappling, but his might truly comes from his ability to take a shot and keep responding along with his own offense. His striking accuracy could use some work at 43% in his first appearance, but he’s way more of a reactionary fighter and has more of a probability to catch Barlow with one in all his counter shots.

Ultimately, Santos may have to stay light on his feet and in constant motion when working against the striking of Barlow. He’ll be coping with a small reach and height discrepancy, so the majority of his damage may have to be done from contained in the pocket and in close. Don’t sleep on the submission abilities of Santos if these two find yourself engaging on the bottom.

Final Danny Barlow-Djorden Santos prediction & pick

This ought to be a fun fight as each men have been known to complete bouts up to now, but they’re each coming into this fight off losses and hungry for a win. Danny Barlow is the clear favorite here due to his physical size and skill to make use of his long frame within the striking. Djorden Santos is much less fluid of a striker but can definitely make this an interesting fight if he’s capable of catch Barlow clean on the chin.

Barlow ought to be defensively cautious given his last defeat, but I do not expect him to be hesitant along with his own striking. Given his ability to harm opponents with the jab while keeping himself protected, Barlow ought to be much improved from an all-around striking standpoint this time around. We’ll roll with him because the betting favorite to win inside the gap with a knockout finish.

Final Danny Barlow-Djorden Santos Prediction & Pick: Danny Barlow (-325); UNDER 2.5 Rounds (-154)