Fox is investing in medicine with its upcoming comedy drama Best Medicine, which pulls inspiration from the beloved series Doc Martin.
Before expanding their roster with Best Medicine, Fox found success with The Resident, which ran for six seasons before its conclusion in 2023. The network then ordered Doc to series and has continued to seek out success with the medical drama.
In May 2025, Fox confirmed Best Medicine was in development, with Josh Charles playing the titular role.
“Comedy isn’t one genre for us. We don’t just take a look at it as, like, half-hour live-action comedy,” President of Fox Television Network Michael Thorn told reporters on the time. “We take a look at it as animation, after all comedy, but we take a look at it, like, with a one-hour comedy like Best Medicine. Even our game shows like The 1% Club, we take a look at as a comedy first and a game show second. And so this just felt prefer it was form of an ideal opportunity for us to expand the way in which that we check with our audience through comedy.”
He continued: “We love this story for its humor, charm, optimism, and edge, not to say its standing as a proven 10 season global hit out of the U.K. It’s been almost a decade since we’ve had a one hour comedy on Fox. So introducing this signature Fox character and his story is the right fit for us. There really is nothing like Best Medicine on broadcast TV today.”
Thorn expressed excitement at developing a more comedic medical series.
“A pair things we love concerning the original format that Liz Tuccillo, who’s adapting the American version, just captured so well is the unique has this old, funny, surprising, flawed, no filter character who happens to be an excellent doctor. And that form of messy characters work so well for our audience on our air,” he added. “And we predict Liz did an amazing job capturing it and the way lucky are we’d have Josh Charles to embody the American version. After which the opposite thing concerning the original that we love, it’s really this type of wonderful, quirky ensemble of supporting characters. There’s an amazing romance, it’s an aspirational small town setting, and it just appears like all of those qualities put to the typewriter of Liz just really works so well for us.”
Keep scrolling for every little thing to find out about Best Medicine — and its connection to Doc Martin:
When Will ‘Best Medicine’ Premiere on Fox?
The medical comedy is currently filming in upstate Latest York and is slated to premiere in January 2026. Best Medicine comes from author Liz Tuccillo and has already received a series order from Fox.
What Is the Show About?
In accordance with the official synopsis, Best Medicine follows a health care provider who “moves from the town of Boston, Massachusetts, to a small practice within the east-coast fishing village where he vacationed as a baby.”
Who Makes Up the Forged?
Charles leads the solid as Dr. Martin Best alongside Abigail Spencer, who will play Louisa Glasson, an enthralling local school teacher who “immediately gets off on the improper foot with Martin Best, yet she’s intrigued by him,” in response to the official character description.
Then there may be Josh Segarra a.k.a Sheriff Mark Mylow, who’s described as “an enthralling lawman who knows every inch of his town. Still healing from a recent breakup with Louisa, he’s desperate to get to know the brand new doctor, forming a little bit of a love triangle as sparks begin to fly between Best and his former flame.”
Cree will bring to life Elaine Denton, who “has big dreams and plans to get out of the town ASAP. She’s charming but inept at her job and too focused on becoming a YouTube star. She also has no idea why Martin is all the time upset together with her.”
Rounding out the solid is Annie Potts‘ Aunt Joan, “a robust, sturdy, lobster woman who still goes out on daily basis on her boat, and nobody higher tell her to stop in the event that they know what’s good for them.”
“She’s salt of the earth and underneath her stern demeanor she has a heart as big because the sea. She loves her small Maine town and her cranky nephew,” the synopsis continued. “She’s loyal but stubborn, the form of woman you desire to be around and never disappoint. But even Joan can have just a few secrets — including why she ended up losing touch with Martin so a few years before.”
Didi Conn plays councilwoman Geneva Potter, Clea Lewis is pharmacist Sally Mylow, Stephen Spinella and Jason Veasey are the “happily married proprietors” of The Salty Breeze. Cindy De La Cruz is the schoolteacher Jeannie while John DiMaggio is the handyman Burt Large, Carter Shimp is Burt’s son Al Large and dog solid member Wattson, who will play pup Copernicus.
What Is ‘Best Medicine’ Based On?
Fox’s upcoming series is predicated on the ITV series Doc Martin, which aired from 2004 to 2022. The show was created by Dominic Minghella, who developed the character of Dr. Martin Bamford from the 2000 film Saving Grace.
Doc Martin starred Martin Clunes, Caroline Catz, Ian McNeice, Joe Absolom, Selina Cadell, John Marquez, Eileen Atkins and Jessica Ransom.
Are ‘Doc Martin’ Stars on ‘Best Medicine’?
In October 2025, it was announced that OG Doc Martin star Clunes will appear within the role of Martin Best’s father.